Pathways to the co-management of protected areas and native title in Australia

In recent decades, various forms of co-management of national parks and other protected areas by governments and Indigenous people have come to the fore. This has occurred as Indigenous peoples have progressively demanded greater access to and decision- making power over their traditional lands. The response of governments has also seen the aligning of a number of policy approaches that have contributed to an increase in attention to co-management. In this paper, we are concerned with the regulatory and non-regulatory ‘formal institutions’ defined by Maclean et al. (2012: 21) as ‘the rules, regulations and social norms that are formalised in conventions, strategies, policy and plans’ that frame the entrance to co- management arrangements. The paper first provides an overview of these institutions in Commonwealth, state and territory jurisdictions, and discusses a number of evolving pathways to co-management in Australia, in particular native title. It then makes some jurisdictional comparisons of these institutional arrangements, questioning their relative value and whether their diversity is creating significant inequities among Aboriginal people

Indigenous governance bibliography

AIATSIS has compiled this bibliography on Indigenous governance as part of its Indigenous Governance Building: Mapping current and future research and practical resource needs project. It is to be read in conjunction with an AIATSIS bibliography on free, prior and informed consent, engagement and consultation, and other bibliographies relating to various aspects of Indigenous governance which have been included in the following pages and are also available via the project webpage linked above. The term ‘governance’ is wide reaching and it has not been possible to cover all Indigenous governance related topics comprehensively. Within the context of this project governance is broadly defined as a cultural construct where the principles and standards of what constitutes ‘good’, ‘good enough’, ‘strong’, ‘legitimate’, ‘ineffective’, ‘corrupt’ or ‘bad’ governance are informed by culturally-based values, traditions and ideologies; and vary significantly between different societies. There is no end-point goal of ‘perfect’ governance that will eventually be achieved in the future. Rather, governance is adaptive according to context and circumstances. This means it may swing between effectiveness and dysfunction. It is to be found as much in people’s daily self-determined practices, processes and relationships, as it is in visible structures and formal institutions

No More Business as Usual: The Need for Participatory Indigenous Development Policy and Skilled Practice

This paper explores what is required to enable First People to be genuinely able to participate in their own development in line with their right to self-determination and free prior and informed consent. It examines current major directions and opportunities in government policies and argues that ‘business as usual’ processes of engagement and communication will need to change significantly if people are to experience genuine participation in any place-based processes. It finishes with a call for new institutional support to enable effective participatory development to occur

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Toni Bauman

Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Date:1983-1

&#039;You mob all agree?&#039; The chronic emergency of culturally competent engaged Indigenous problem solving

Toni Bauman writes that responses to the Commonwealth Government\u27s national emergency approach to Aboriginal communities in the Northern Territory have emphasised the need for \u27consultation\u27 yet it might not be \u27consultation\u27 that is actually required, at least in the way it has been practised, as something \u27done\u27 to Indigenous people